Chapter 18

Microbial Conversion of Bio-Based Chemicals: Present and Future Prospects (pp. 301-328)
Authors:  (Huibin Zou, Guang Zhao and Mo Xian, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong, China)
The fast development of microbial biotechnology has enabled innovative
bioconversion processes for the production of an extensive range of bio-based chemicals
from renewable biomass. However, in order to economically and technically compete
with petroleum-based chemicals, it is essential to develop robust microbes and efficient
processing techniques that are capable of producing bio-chemicals with high performance
and low production cost. Recently, the strategies of developing microbial strains using
metabolic engineering techniques have been successfully applied to the industrial
production of several value-added chemicals. This review summarizes the key economic
factors and relative advanced biotechnologies for developing bio-based chemicals, and
gives several successful commodity examples. In addition, the review addresses the
current trends in developing value-added bioproducts, which represent the near-term
opportunities of robust microbial strains for industrial applications.